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Free Access JACN Article: A 7-Year Longitudinal Trial of the Safety and Efficacy of a Calcium Supplement Used to Enhance Bone Mineral Density

May 2016--A recent study from the Journal of the American College of Nutrition (JACN), examines the safety and efficacy of a vitamin/mineral enhanced plant-sourced calcium supplement [AlgaeCal  (AC)] in female consumers who had taken the supplement from 1 to 7 years. The article “A 7-Year Longitudinal Trial of the Safety and Efficacy of a Vitamin/Mineral Enhanced Plant-Sourced Calcium Supplement” is published in JACN Issue 35(2) 2016, the official publication of the American College of Nutrition.

Consumers who had completed at least one dual-energy x-ray absorptiometry (DEXA) bone mineral density (BMD) scan (N = 172) and/or blood chemistry test (N = 30) and purchased AlgaeCal (AC) from 1 to 7 years were contacted and offered complimentary repeat tests. Safety and efficacy were examined by annualized changes in a 45-measurement blood chemistry panel and changes in BMD.

No adverse effects or safety concerns were found in any of the annualized within-group annualized changes in the 45 blood chemistries or in between-group changes in a similar control group (n = 5070) who completed the same measurements. With regard to BMD, consistent and statistically significant within-group increases were found for the 7-year study period and when compared to expected BMD changes in 3 large databases or the combination (N = 25,885) of the 3 databases. Data from this study suggest that AlgaeCal (AC) supplement was associated with a significant annualized and linear increase in BMD of 1.04% per year, 7.3% over the 7-year study period. These results stand in marked contrast to normative or expected changes of −0.4%/y from 3 different databases or in a combination of all 3 databases (N = 16,289).

The results showed that no evidence was found in cardiovascular risk as measured by adverse changes in blood lipids, nor was any evidence found of a diminished efficacy over the 7-year study period because gains in BMD were consistent and linear over the 7-year study period, averaging 1.04% per year over the 7-year study. 

The results are also consistent with earlier short-term studies suggesting that the AlgaeCal (AC) supplement can facilitate significant increases in total body BMD in contrast to studies suggesting that calcium supplements can only slow down age-related declines in BMD.

FREE ACCESS: A 7-Year Longitudinal Trial of the Safety and Efficacy of a Vitamin/Mineral Enhanced Plant-Sourced Calcium Supplement
Gilbert R. Kaats PhD, FACN, Harry G. Preuss MD, MACN, Sidney Stohs PhD, FACN, CNS & Nicholas Perricone MD, FACN
Volume 35, Issue 2, 2016 

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Frequency Increase in 2016 – Now published eight times per year, the Journal of the American College of Nutrition continues to provide original and innovative research in nutrition with useful application for researchers, physicians, and other health care professionals. Journal Citation Reports® ranks Journal of the American College of Nutrition in the category of Nutrition & Dietetics (Science) with an Impact Factor of 1.453 and a 2.867 5-Year Impact Factor (© 2015 Thomson Reuters, 2014 Journal Citation Reports®). Submit manuscripts at http://mc.manuscriptcentral.com/JACN. Follow the American College of Nutrition on Twitter
 
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The American College of Nutrition® has been dedicated since 1959 to enhancing clinical nutrition. The College strives to stimulate nutrition research and publication, elevate nutrition knowledge among researchers and clinicians, and provide practical guidance on clinical nutrition. Society Contact: Michael Stroka, JD, MBA, MS, CNS, Executive Director, American College of Nutrition, Tel: 727-446-6086 or Email: mstroka@americancollegeofnutrition.org

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